Whole Genome Analysis Report

Disclaimer

The service provided by Khon Kaen University National Phenome Institute (KKUNPhI) are currently for research use only. As they have not been submitted for review to any regulatory agency/notified body for clinical diagnostics, caution must be excercisrd when describing the application of KKUNPhI service in the clinical research field.

* This report is for research use only

Overview

This report presents the findings of whole genome sequencing analysis. It provides detailed associations between genetic variants and various diseases and traits, highlighting the mapped genes, relevant SNPs, and associated gene regions.

453,471
Variants have been found in your genome.
SNPs54.88%248,885 Positions
INS28.26%128,169 Positions
COMPLEX15.89%72,046 Positions
DEL0.96%4,371 Positions

Termonology

Gene: Gene is a segment of DNA that serves as a blueprint for producing proteins or functional RNA molecules, which carry out vital biological functions in the body. Genes are the basic units of heredity, passed from parents to offspring, and play a crucial role in determining traits and regulating cellular processes.

Single Nucleotide Polymorphism (SNP): A SNP is a variation in a single nucleotide in the DNA sequence that occurs at a specific position in the genome and is common in a population. SNPs can influence traits, disease susceptibility, and drug response.

Insertion (INS): An insertion is the addition of one or more nucleotides to a DNA sequence.

Deletion (DEL): A deletion is the removal of one or more nucleotides from a DNA sequence.

Complex (COMPLEX): A complex variant is a combination of insertions, deletions, and substitutions

Alleles: An allele is a variant form of a gene found at a specific position (locus) on a chromosome. Each allele is inherited, one from each parent.

Mapped Gene: Genes mapped near or overlapping the SNPs.

Chromosomal region: The genomic region associated with the trait or disease.

Risk Allele Frequency (%): The frequency of the risk allele in the population.


Metabolite levels (3-aminoisobutyrate; __Aminoisobutyrate)

Quantification of 3-aminoisobutyrate in a sample.

Region: 5p13.2

SNPs ID: rs180749

Mapped Gene: AGXT2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 96.05 (%)

Platelet forward scatter distribution width

A measurement quantifying some platelet

Region: 19q13.42

SNPs ID: rs1654447

Mapped Gene: RDH13

Group of disease/trait: Other trait

020406080100Your Genetic Risk 84.23 (%)

2-aminoisobutyric acid levels in chronic kidney disease

Quantification of the amount of 2-aminoisobutyric acid in a sample.

Region: 5p13.2

SNPs ID: rs180749

Mapped Gene: AGXT2

Group of disease/trait: Other disease

020406080100Your Genetic Risk 83.0 (%)

Post bronchodilator FEV1/FVC ratio

Description not found

Region: 15q25.1

SNPs ID: rs2568497

Mapped Gene: CRABP1 - IREB2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 81.2 (%)

Post bronchodilator FEV1

Description not found

Region: 15q25.1

SNPs ID: rs2568497

Mapped Gene: CRABP1 - IREB2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 81.1 (%)

Educational attainment

A measure of academic performance through educational benchmarks such as national exams and curriculum assessments.

Region: 2p25.1

SNPs ID: rs1861499

Mapped Gene: LINC00299

Group of disease/trait: Other trait

020406080100Your Genetic Risk 78.58 (%)

Atrial fibrillation (PheCode 427.21)

A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent p waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (cdisc)

Region: 6p22.3

SNPs ID: rs34969716

Mapped Gene: KDM1B

Group of disease/trait: Other trait

020406080100Your Genetic Risk 74.82 (%)

Albumin (mean, inv-norm transformed)

An albumin measurement is a quantification of albumin in blood. serum albumin, the main protein of plasma, has a good binding capacity for water, ca2+, na+, k+, fatty acids, hormones, bilirubin and drugs. its main function is the regulation of the colloidal osmotic pressure of blood. major zinc transporter in plasma, typically binds about 80% of all plasma zinc. low levels of albumin in the blood may indicate liver disease.

Region: 1p35.1

SNPs ID: rs16835227

Mapped Gene: RNF19B - AK2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 74.81 (%)

Albumin (minimum, inv-norm transformed)

An albumin measurement is a quantification of albumin in blood. serum albumin, the main protein of plasma, has a good binding capacity for water, ca2+, na+, k+, fatty acids, hormones, bilirubin and drugs. its main function is the regulation of the colloidal osmotic pressure of blood. major zinc transporter in plasma, typically binds about 80% of all plasma zinc. low levels of albumin in the blood may indicate liver disease.

Region: 1p35.1

SNPs ID: rs16835227

Mapped Gene: RNF19B - AK2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 74.81 (%)

Atrial fibrillation and flutter (PheCode 427.2)

A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent p waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (cdisc)

Region: 6p22.3

SNPs ID: rs34969716

Mapped Gene: KDM1B

Group of disease/trait: Other trait

020406080100Your Genetic Risk 74.81 (%)

Smoking initiation

initation of the habit of smoking, the inhaling and exhaling of tobacco smoke.

Region: 11p15.1

SNPs ID: rs7122118

Mapped Gene: TPH1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 74.8 (%)

25-hydroxyvitamin D levels (skin colour stratified)

A quantification of Vitamin D levels, typically in blood. Vitamin D includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE (MeSH). 25-hydroxyvitamin D or calcifediol, a prehormone precursor of vitamin D, is widely used as a proxy to quanitfy vitamin D levels in blood.

Region: 7p15.3

SNPs ID: rs10085881

Mapped Gene: SP4 - DNAH11

Group of disease/trait: Other trait

020406080100Your Genetic Risk 72.0 (%)

Serum 25-Hydroxyvitamin D levels (conditioned on BMI)

A quantification of Vitamin D levels, typically in blood. Vitamin D includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE (MeSH). 25-hydroxyvitamin D or calcifediol, a prehormone precursor of vitamin D, is widely used as a proxy to quanitfy vitamin D levels in blood.

Region: 7p15.3

SNPs ID: rs10085881

Mapped Gene: SP4 - DNAH11

Group of disease/trait: Other trait

020406080100Your Genetic Risk 71.78 (%)

Albumin (maximum, inv-norm transformed)

An albumin measurement is a quantification of albumin in blood. serum albumin, the main protein of plasma, has a good binding capacity for water, ca2+, na+, k+, fatty acids, hormones, bilirubin and drugs. its main function is the regulation of the colloidal osmotic pressure of blood. major zinc transporter in plasma, typically binds about 80% of all plasma zinc. low levels of albumin in the blood may indicate liver disease.

Region: 1p35.1

SNPs ID: rs150944423

Mapped Gene: RNF19B - AK2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 71.38 (%)

Phospholipids to total lipids ratio in medium HDL

The measurement of HDL cholesterol in blood used as a risk indicator for heart disease.

Region: 6p21.31

SNPs ID: rs2744973

Mapped Gene: ILRUN

Group of disease/trait: Other trait

020406080100Your Genetic Risk 69.32 (%)

Phospholipids to total lipids ratio in large LDL

Quantification of the ratio of phospholipids to total lipids in a sample.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 69.32 (%)

Free cholesterol to total lipids ratio in medium HDL

The measurement of HDL cholesterol in blood used as a risk indicator for heart disease.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Cardiovascular disease

020406080100Your Genetic Risk 69.32 (%)

White blood cell count

The number of myeloid leukocytes in a specified volume of blood, usually 1 cubic millimeter.

Region: 6q23.3

SNPs ID: rs610604

Mapped Gene: TNFAIP3

Group of disease/trait: Other trait

020406080100Your Genetic Risk 67.44 (%)

Immature platelet count

The number of immature platelets in a specified volume of blood.

Region: 6p22.2

SNPs ID: rs2281073

Mapped Gene: CARMIL1 - SCGN

Group of disease/trait: Other trait

020406080100Your Genetic Risk 67.26 (%)

Sodium-coupled monocarboxylate transporter 1 levels

Quantification of sodium-coupled monocarboxylate transporter 1 in a sample.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 66.0 (%)

Hand grip strength

Quantification of the force applied by the hand to pull on or suspend from objects

Region: 17q21.32

SNPs ID: rs2288278

Mapped Gene: HOXB3, HOXB-AS3

Group of disease/trait: Other trait

020406080100Your Genetic Risk 65.8 (%)

Free cholesterol levels in HDL

The measurement of HDL cholesterol in blood used as a risk indicator for heart disease.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Cardiovascular disease

020406080100Your Genetic Risk 65.19 (%)

Apolipoprotein A1 levels

Is a quantification of apolipoprotein A 1 in a sample. It is encoded in humans by the APOA1 gene and is the major protein component of high density lipoprotein (HDL) in plasma. Apolipoprotein A 1 relates to lower observational risk of coronary artery disease.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 64.98 (%)

Asthma

A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Immune system disease

020406080100Your Genetic Risk 64.9 (%)

Estimated glomerular filtration rate (creatinine)

measurement of the flow rate of filtered fluid through the kidney, calculated either by comparative measurements of substances in the blood and urine, or estimated from a blood test

Region: 19p13.11

SNPs ID: rs1469024

Mapped Gene: IQCN

Group of disease/trait: Other trait

020406080100Your Genetic Risk 64.79 (%)

Triglycerides to total lipids ratio in medium VLDL

quantification of the amount of very low density lipoprotein cholesterol in a sample

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 64.49 (%)

Free cholesterol to total lipids ratio in medium LDL

Quantification of the ratio of free cholesterol to total lipids in a sample.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Cardiovascular disease

020406080100Your Genetic Risk 64.49 (%)

Triglycerides to total lipids ratio in IDL

Quantification of the amount of intermediate density lipoprotein in a sample.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 64.48 (%)

Phospholipids to total lipids ratio in IDL

Quantification of the amount of intermediate density lipoprotein in a sample.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 64.39 (%)

Concentration of very small VLDL particles

quantification of the amount of very low density lipoprotein cholesterol in a sample

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 64.35 (%)

Remnant cholesterol (non-HDL, non-LDL -cholesterol)

Measurement of remnant cholesterol (remnant lipoprotein), which is an atherogenic lipoprotein composed primarily of very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL).

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Cardiovascular disease

020406080100Your Genetic Risk 64.34 (%)

Triglycerides in very large HDL

Quantification of triglycerides in very large hdl.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 64.33 (%)

Hypopotassemia (PheCode 276.14)

Any disorder caused by an insufficient amount or availability of potassium, which generally manifests with myalgia, tetany, hypotension, polyuria, and polydipsia.

Region: 5q23.3

SNPs ID: rs7726795

Mapped Gene: FBN2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 63.44 (%)

Plasma 2,6-dihydroxybenzoic acid levels in chronic kidney disease

Quantification of the amount of 2,6-dihydroxybenzoic acid in a sample.

Region: 3q29

SNPs ID: rs2342307

Mapped Gene: PCYT1A, SLC51A

Group of disease/trait: Other disease

020406080100Your Genetic Risk 63.0 (%)

Metabolite levels (leucylserine)

Ontology not covered

Region: 4q35.2

SNPs ID: rs4253281

Mapped Gene: KLKB1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 62.15 (%)

Myeloproliferative neoplasms

A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. it is primarily a neoplasm of adults. (who 2008)

Region: 3q21.3

SNPs ID: rs9864772

Mapped Gene: LINC01565 - RPN1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 60.75 (%)

Dementia with Lewy bodies

A progressive form of dementia characterized by the presence of protein deposits called Lewy bodies in the midbrain and cerebral cortex, and loss of cholinergic and dopaminergic neurons. The signs and symptoms overlap with Alzheimer and Parkinson disease.

Region: 16p11.2

SNPs ID: rs897984

Mapped Gene: MIR4519, BCL7C, MIR762HG

Group of disease/trait: Nervous system disease

020406080100Your Genetic Risk 60.0 (%)

Trauma exposure

Quantification of some aspect of trauma exposure.

Region: 19q13.32

SNPs ID: rs770444611

Mapped Gene: CCDC8 - PNMA8C

Group of disease/trait: Other trait

020406080100Your Genetic Risk 59.0 (%)

Alzheimer's disease with no specific cognitive domain impairment

A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Region: 2q31.1

SNPs ID: rs4972634

Mapped Gene: LINC01960 - RPSAP24

Group of disease/trait: Nervous system disease

020406080100Your Genetic Risk 59.0 (%)

Body size at age 10

Description of an individual's body size at age 10 compared to average, as reported by the individual.

Region: 8q21.13

SNPs ID: rs35918296

Mapped Gene: HNF4G - RNU2-54P

Group of disease/trait: Other trait

020406080100Your Genetic Risk 58.62 (%)

Neuritic plaque

Quantification of neuritic (senile) plaques in the brain, senile plaques (also known as neuritic plaques, senile druse and braindruse) are extracellular deposits of amyloid beta in the grey matter of the brain.[1][2] degenerative neural structures and an abundance of microglia and astrocytes can be associated with senile plaque deposits. these deposits can also be a byproduct of senescence (ageing). however, large numbers of senile plaques and neurofibrillary tangles are characteristic features of alzheimer's disease. abnormal neurites in senile plaques are composed primarily of paired helical filaments, a component of neurofibrillary tangles.[3] the plaques are variable in shape and size, but are on average 50 µm in size.[4] in alzheimer's disease they are primarily composed of amyloid beta peptides.

Region: 12p13.31

SNPs ID: rs7294478

Mapped Gene: C1RL-AS1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 58.47 (%)

Metabolite levels (arginine)

Quanitification of argininine levels in a sample.

Region: 4q35.2

SNPs ID: rs4253281

Mapped Gene: KLKB1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 58.05 (%)

Free cholesterol to total lipids ratio in very large VLDL

Quantification of the ratio of free cholesterol to total lipids in a sample.

Region: 8p23.1

SNPs ID: rs11986122

Mapped Gene: MSRA

Group of disease/trait: Cardiovascular disease

020406080100Your Genetic Risk 57.73 (%)

Cholesteryl esters to total lipids ratio in medium VLDL

Quantification of the ratio of cholesteryl esters to total lipids in a sample.

Region: 8p23.1

SNPs ID: rs11986122

Mapped Gene: MSRA

Group of disease/trait: Other trait

020406080100Your Genetic Risk 57.72 (%)

Cholesterol to total lipids ratio in medium VLDL

Quantification of the ratio of cholesterol to total lipids in a sample.

Region: 8p23.1

SNPs ID: rs11986122

Mapped Gene: MSRA

Group of disease/trait: Cardiovascular disease

020406080100Your Genetic Risk 57.72 (%)

Heparin-induced thrombocytopenia

A reduction in the number of circulating thrombocytes.

Region: 12q24.33

SNPs ID: rs905227

Mapped Gene: ZNF84

Group of disease/trait: Other trait

020406080100Your Genetic Risk 56.0 (%)

Electrocardiogram morphology (amplitude at temporal datapoints)

Recording of the moment-to-moment electromotive forces of theâ heartâ as projected onto various sites on the body's surface, delineated as a scalar function of time. the recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is aâ cathode ray tube display.

Region: 11q22.1

SNPs ID: rs671333

Mapped Gene: ARHGAP42

Group of disease/trait: Other trait

020406080100Your Genetic Risk 55.52 (%)

Coronary artery disease

An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.

Region: 4q28.3

SNPs ID: rs7439567

Mapped Gene: PCDH18 - LINC02172

Group of disease/trait: Cardiovascular disease

020406080100Your Genetic Risk 55.36 (%)

Mean corpuscular hemoglobin

The MCH is the average mass of hemoglobin per red blood cell in a sample of blood and is calculated by dividing the total mass of hemoglobin by the RBC count

Region: 17q11.2

SNPs ID: rs10853129

Mapped Gene: MIR4732 - FLOT2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 55.18 (%)

Red cell distribution width

Red blood cell distribution width (rdw or rdw-cv or rcdw and rdw-sd) is a measure of the range of variation of red blood cell (rbc) volume that is reported as part of a standard complete blood count. usually red blood cells are a standard size of about 6-8 μm in diameter. certain disorders, however, cause a significant variation in cell size. higher rdw values indicate greater variation in size. normal reference range of rdw-cv in human red blood cells is 11.5-14.5%.[1] if anemia is observed, rdw test results are often used together with mean corpuscular volume (mcv) results to determine the possible causes of the anemia. it is mainly used to differentiate an anemia of mixed causes from an anemia of a single cause.

Region: 13q12.2

SNPs ID: rs17085633

Mapped Gene: MTIF3

Group of disease/trait: Other trait

020406080100Your Genetic Risk 51.81 (%)

Highest math class taken (MTAG)

Is the mental process necessary to acquire knowledge or skill in the measurement, properties, and relationships of quantities and sets, using numbers and symbols (mathematics)

Region: 6q16.1

SNPs ID: rs12208753

Mapped Gene: MMS22L - MIR2113

Group of disease/trait: Other trait

020406080100Your Genetic Risk 50.09 (%)

Gut microbiota (bacterial taxa, rank normal transformation method)

Quantification of some aspect of an individual's micrbiome of the gut

Region: 17q12

SNPs ID: rs317386

Mapped Gene: ASIC2

Group of disease/trait: Digestive system disease

020406080100Your Genetic Risk 50.09 (%)

Highest math class taken

Is the mental process necessary to acquire knowledge or skill in the measurement, properties, and relationships of quantities and sets, using numbers and symbols (mathematics)

Region: 6q16.1

SNPs ID: rs12208753

Mapped Gene: MMS22L - MIR2113

Group of disease/trait: Other trait

020406080100Your Genetic Risk 49.91 (%)

Core binding factor acute myeloid leukemia

Acute myeloid leukemia (aml) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. all of them are characterized by clonal expansion of myeloid blasts. aml manifests by fever, pallor, anemia, hemorrhages and recurrent infections.

Region: 14q31.1

SNPs ID: rs1952373; rs8006900; rs7152583; rs8007728; rs2031857; rs17650363; rs8004086

Mapped Gene: EEF1A1P2 - LINC02311; EEF1A1P2 - LINC02311; EEF1A1P2 - LINC02311; EEF1A1P2 - LINC02311; EEF1A1P2 - LINC02311; EEF1A1P2 - LINC02311; EEF1A1P2 - LINC02311

Group of disease/trait: Cancer

020406080100Your Genetic Risk 49.9 (%)

Secondary hypothyroidism (PheCode 244.1)

Abnormally low levels of thyroid hormone.

Region: 14q13.2

SNPs ID: rs1742869

Mapped Gene: LINC00609

Group of disease/trait: Metabolic disease

020406080100Your Genetic Risk 49.08 (%)

Bile salt-activated lipase levels

Is a quantification of some protein, typically obtained from an individual with the intention of using the measurement in some diagnostic process.

Region: 10p11.23

SNPs ID: rs793095

Mapped Gene: LINC02664

Group of disease/trait: Other trait

020406080100Your Genetic Risk 48.0 (%)

Uterine fibroids

A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.

Region: 13q14.11

SNPs ID: rs6563812

Mapped Gene: LINC00598

Group of disease/trait: Other trait

020406080100Your Genetic Risk 47.91 (%)

Neuropilin-2 levels

Ontology not covered

Region: 4q35.2

SNPs ID: rs4253281

Mapped Gene: KLKB1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 47.27 (%)

Plasma maltol sulfate levels in chronic kidney disease

The quantification of some metabolite.

Region: 16p11.2

SNPs ID: rs193628

Mapped Gene: SGF29

Group of disease/trait: Other disease

020406080100Your Genetic Risk 47.0 (%)

Bioavailable testosterone levels

is a quantification of testosterone, typically in serum. Testosterone is a steroid hormone.Testosterone measurement is used in the diagnosis of precocious or delayed puberty, infertility (in men and women), ovarian tumours, adrenal tumours and pituitary disorders.

Region: 3p25.3

SNPs ID: rs573833

Mapped Gene: ATP2B2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 46.31 (%)

Urine X-17674 levels in chronic kidney disease

The quantification of some metabolite.

Region: 16p11.2

SNPs ID: rs193628

Mapped Gene: SGF29

Group of disease/trait: Other disease

020406080100Your Genetic Risk 46.0 (%)

Urine maltol sulfate levels in chronic kidney disease

The quantification of some metabolite.

Region: 16p11.2

SNPs ID: rs193628

Mapped Gene: SGF29

Group of disease/trait: Other disease

020406080100Your Genetic Risk 46.0 (%)

Urine prolylglycine levels in chronic kidney disease

Quantification of the amount of prolylglycine in a sample.

Region: 16q24.3

SNPs ID: rs2434858

Mapped Gene: DPEP1

Group of disease/trait: Other disease

020406080100Your Genetic Risk 46.0 (%)

Serum levels of protein CHRDL2

Quantification of the levels of some protein in a blood sample

Region: 11q13.4

SNPs ID: rs6592590

Mapped Gene: POLD3 - RN7SKP297

Group of disease/trait: Other trait

020406080100Your Genetic Risk 44.8 (%)

red cell diameter width (RDW, maximum, inv-norm transformed)

Red blood cell distribution width (rdw or rdw-cv or rcdw and rdw-sd) is a measure of the range of variation of red blood cell (rbc) volume that is reported as part of a standard complete blood count. usually red blood cells are a standard size of about 6-8 μm in diameter. certain disorders, however, cause a significant variation in cell size. higher rdw values indicate greater variation in size. normal reference range of rdw-cv in human red blood cells is 11.5-14.5%.[1] if anemia is observed, rdw test results are often used together with mean corpuscular volume (mcv) results to determine the possible causes of the anemia. it is mainly used to differentiate an anemia of mixed causes from an anemia of a single cause.

Region: 6p22.3

SNPs ID: rs4441945

Mapped Gene: RPL21P61 - LNC-LBCS

Group of disease/trait: Other trait

020406080100Your Genetic Risk 43.73 (%)

red cell diameter width (RDW, mean, inv-norm transformed)

Red blood cell distribution width (rdw or rdw-cv or rcdw and rdw-sd) is a measure of the range of variation of red blood cell (rbc) volume that is reported as part of a standard complete blood count. usually red blood cells are a standard size of about 6-8 μm in diameter. certain disorders, however, cause a significant variation in cell size. higher rdw values indicate greater variation in size. normal reference range of rdw-cv in human red blood cells is 11.5-14.5%.[1] if anemia is observed, rdw test results are often used together with mean corpuscular volume (mcv) results to determine the possible causes of the anemia. it is mainly used to differentiate an anemia of mixed causes from an anemia of a single cause.

Region: 6p22.3

SNPs ID: rs4441945

Mapped Gene: RPL21P61 - LNC-LBCS

Group of disease/trait: Other trait

020406080100Your Genetic Risk 43.73 (%)

Mean spheric corpuscular volume

A mean corpuscular volume is the result of calculation of the mean volume of erythrocytes in a blood sample.

Region: 11q24.3

SNPs ID: rs2250322

Mapped Gene: FLI1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 43.68 (%)

Mean corpuscular volume

A mean corpuscular volume is the result of calculation of the mean volume of erythrocytes in a blood sample.

Region: 11q24.3

SNPs ID: rs2250322

Mapped Gene: FLI1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 43.68 (%)

high density lipoprotein cholesterol (HDLC, maximum, inv-norm transformed)

The measurement of HDL cholesterol in blood used as a risk indicator for heart disease.

Region: 6p21.31

SNPs ID: rs4711396

Mapped Gene: ILRUN

Group of disease/trait: Cardiovascular disease

020406080100Your Genetic Risk 42.9 (%)

high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed)

The measurement of HDL cholesterol in blood used as a risk indicator for heart disease.

Region: 6p21.31

SNPs ID: rs4711396

Mapped Gene: ILRUN

Group of disease/trait: Cardiovascular disease

020406080100Your Genetic Risk 42.9 (%)

Cholesteryl ester levels

Quantification of the amount of esterified cholesterol in a sample.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 42.48 (%)

Appendicular lean mass

Appendicular lean mass is a measurement of skeletal strength of lower limbs and is used as a predictive measure of hip fracture.

Region: 3q21.3

SNPs ID: rs4073154

Mapped Gene: H1-10-AS1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 42.26 (%)

Allergic disease (asthma, hay fever or eczema)

An immune response that occurs following re-exposure to an innocuous antigen, and that requires the presence of existing antibodies against that antigen. This response involves the binding of IgE to mast cells, and may worsen with repeated exposures.

Region: 5q31.3

SNPs ID: rs740474

Mapped Gene: DIAPH1

Group of disease/trait: Immune system disease

020406080100Your Genetic Risk 42.0 (%)

Systolic blood pressure

The blood pressure during the contraction of the left ventricle of the heart.

Region: 4q28.3

SNPs ID: rs7439567

Mapped Gene: PCDH18 - LINC02172

Group of disease/trait: Cardiovascular disease

020406080100Your Genetic Risk 41.55 (%)

Phosphatidylcholine (15:0_18:2) levels

Ontology not covered

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 40.84 (%)

Phosphatidylcholine (17:0_18:2) levels

Ontology not covered

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 40.84 (%)

Phosphatidylcholine (O-18:2_16:0) levels

Ontology not covered

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 40.84 (%)

Phosphatidylinositol (18:0_18:2) levels

Ontology not covered

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 40.84 (%)

Eosinophil percentage of white cells

A calculated measurement in which the number of eosinophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. an eosinophil is a granular leukocyte having a nucleus with two lobes connected by a thread of chromatin, and cytoplasm containing coarse, round granules of uniform size that stain readily with eosin and other acid dyes.

Region: 8p21.2

SNPs ID: rs4733063

Mapped Gene: PTK2B

Group of disease/trait: Other trait

020406080100Your Genetic Risk 39.75 (%)

Hemoglobin A1c levels

A quantification of glycated A1c hemoglobin in blood used as an index for blood glucose level over several months.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 39.14 (%)

Matrix metalloproteinase-9 levels

The determination of the amount of matrix metalloproteinase-9 in a sample

Region: 17q21.1

SNPs ID: rs3826331

Mapped Gene: PSMD3

Group of disease/trait: Other trait

020406080100Your Genetic Risk 39.0 (%)

COVID-19 (hospitalized vs tested, not hospitalized)

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Region: 6p22.3

SNPs ID: rs493024

Mapped Gene: ID4 - RPL29P17

Group of disease/trait: Other trait

020406080100Your Genetic Risk 38.72 (%)

COVID-19 (hospitalized vs population)

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Region: 6p22.3

SNPs ID: rs493024

Mapped Gene: ID4 - RPL29P17

Group of disease/trait: Other trait

020406080100Your Genetic Risk 38.5 (%)

Ulcerative colitis

An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.

Region: 2q24.1

SNPs ID: rs8179646

Mapped Gene: LINC01958 - RPLP0P7

Group of disease/trait: Digestive system disease

020406080100Your Genetic Risk 38.0 (%)

BMI at birth

An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)

Region: 17p13.1

SNPs ID: rs739669

Mapped Gene: DLG4, ACADVL

Group of disease/trait: Other trait

020406080100Your Genetic Risk 37.7 (%)

Longevity

The length of time of an organism's life.

Region: 14q23.3

SNPs ID: rs1950902

Mapped Gene: MTHFD1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 37.0 (%)

Myeloblastin levels

The determination of the amount of myeloblastin in a sample

Region: 19p13.3

SNPs ID: rs3786991

Mapped Gene: AZU1 - PRTN3

Group of disease/trait: Other trait

020406080100Your Genetic Risk 36.39 (%)

Triglyceride to HDL cholesterol ratio

Quantification of the ratio of triglyceride to hdl cholesterol in a sample

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Cardiovascular disease

020406080100Your Genetic Risk 35.1 (%)

Aspartate aminotransferase platelet ratio index in high alcohol intake

Quantification of the invasion of fibrous connective tissue into the liver, typically by histological assessment of biopsy samples.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 35.02 (%)

Asthma in any disease

A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Immune system disease

020406080100Your Genetic Risk 35.0 (%)

Serum alkaline phosphatase levels

Alkaline phosphatase measurement is a quantification of alkaline phosphatase in blood. ap is a marker for bone and liver disease.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 35.0 (%)

Phospholipids in large HDL (UKB data field 23560)

Quantification of phospholipids in large hdl.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 34.71 (%)

IgG glycosylation

Quantification of n-linked igg glycans in a serum sample

Region: 6p21.32

SNPs ID: rs1049110

Mapped Gene: HLA-DQB2

Group of disease/trait: Immune system disease

020406080100Your Genetic Risk 34.64 (%)

Glutathione S-transferase Mu 3 levels

Is a quantification of some protein, typically obtained from an individual with the intention of using the measurement in some diagnostic process.

Region: 1p13.3

SNPs ID: rs3754446

Mapped Gene: GSTM2 - GSTM5

Group of disease/trait: Other trait

020406080100Your Genetic Risk 34.49 (%)

1-oleoyl-2-arachidonoyl-GPE (18:1/20:4) levels

Quantification of the amount of 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4) in a sample.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 34.49 (%)

QT interval

The QT interval is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle

Region: 10p12.2

SNPs ID: rs7098978

Mapped Gene: RNU6-413P - ARMC3

Group of disease/trait: Other trait

020406080100Your Genetic Risk 33.0 (%)

Metabolite levels (stearoyl-arachidonoyl-glycerophosphoinositol (1))

Quantification of stearoyl-arachidonoyl-glycerophosphoinositol (1) in a sample.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 32.56 (%)

Cutaneous psoriasis

A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.

Region: 6q23.3

SNPs ID: rs610604

Mapped Gene: TNFAIP3

Group of disease/trait: Immune system disease

020406080100Your Genetic Risk 32.01 (%)

Psoriasis vulgaris

Plaque psoriasis is the most common presentation of psoriasis. it presents as small to large, well demarcated, red, scaly and thickened areas of skin. it most likely to affect elbows, knees, and lower back but may arise on any part of the body.

Region: 6q23.3

SNPs ID: rs610604

Mapped Gene: TNFAIP3

Group of disease/trait: Immune system disease

020406080100Your Genetic Risk 32.01 (%)

Delta-5 desaturase activity response to n3-polyunsaturated fat supplement

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dietary polyunsaturated fatty acid supplement.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 32.0 (%)

Psoriatic arthritis

A type of inflammatory arthritis associated with psoriasis, often involving the axial joints and the peripheral terminal interphalangeal joints. it is characterized by the presence of hla-b27-associated spondylarthropathy, and the absence of rheumatoid factor.

Region: 6q23.3

SNPs ID: rs610604

Mapped Gene: TNFAIP3

Group of disease/trait: Other trait

020406080100Your Genetic Risk 32.0 (%)

Postprandial estimated degree of unsaturation

The determination of the amount of fatty acids present in a sample.

Region: 11q12.2

SNPs ID: rs174566

Mapped Gene: FADS1, FADS2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 31.97 (%)

Atrial fibrillation

A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent p waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (cdisc)

Region: 6p22.3

SNPs ID: rs34969716

Mapped Gene: KDM1B

Group of disease/trait: Other trait

020406080100Your Genetic Risk 31.42 (%)

JT interval

Measurement of the repolarisation phase of the heart's electrical cycle, defined as the difference between the duration of the qt interval and duration of the qrs interval

Region: 6p22.3

SNPs ID: rs34969716

Mapped Gene: KDM1B

Group of disease/trait: Other trait

020406080100Your Genetic Risk 30.67 (%)

Serum levels of protein WFDC1

Quantification of the levels of some protein in a blood sample

Region: 1p13.3

SNPs ID: rs10127790

Mapped Gene: SORT1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 29.96 (%)

Ectonucleoside triphosphate diphosphohydrolase 5 levels

Quantification of the amount of ectonucleoside triphosphate diphosphohydrolase 5 in a sample

Region: 14q24.3

SNPs ID: rs1968105

Mapped Gene: PTGR2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 28.71 (%)

Suffering from nerves

Ontology not covered

Region: 18q21.32

SNPs ID: rs11665052

Mapped Gene: RNU4-17P - MC4R

Group of disease/trait: Other trait

020406080100Your Genetic Risk 26.32 (%)

ICOS ligand levels

The determination of the amount of icos ligand in a sample

Region: 8p23.1

SNPs ID: rs56136595

Mapped Gene: DEFA4 - DEFA8P

Group of disease/trait: Other trait

020406080100Your Genetic Risk 26.0 (%)

Creatinine levels (UKB data field 23478)

A creatinine measurement is a measure of the metabolite creatinine in a sample. For example, in the serum, where it can be used in assessment of kidney function.

Region: 17q12

SNPs ID: rs113414512

Mapped Gene: FBXL20

Group of disease/trait: Other trait

020406080100Your Genetic Risk 25.42 (%)

Cortical surface area

Quantification of the surface area of the cerebral cortex or parts thereof.

Region: 12q23.3

SNPs ID: rs2374977

Mapped Gene: WSCD2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 25.0 (%)

Myeloblastin (analyte X13720.95) levels

Is a quantification of some protein, typically obtained from an individual with the intention of using the measurement in some diagnostic process.

Region: 19p13.3

SNPs ID: rs3786991

Mapped Gene: AZU1 - PRTN3

Group of disease/trait: Other trait

020406080100Your Genetic Risk 24.93 (%)

What is your weight? (pounds, inv-normal transformed)

The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Region: 3q21.3

SNPs ID: rs4073154

Mapped Gene: H1-10-AS1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 22.29 (%)

What is your height? (cm, inv-normal transformed)

The distance from the sole to the crown of the head with body standing on a flat surface and fully extended.

Region: 3q21.3

SNPs ID: rs4073154

Mapped Gene: H1-10-AS1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 20.8 (%)

Smoking initiation (ever regular vs never regular) (MTAG)

self-reported binary measure, used to denote whether an individual is currently or has ever been a smoker

Region: 2q36.3

SNPs ID: rs4674993

Mapped Gene: NYAP2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 20.0 (%)

Smoking initiation (ever regular vs never regular)

self-reported binary measure, used to denote whether an individual is currently or has ever been a smoker

Region: 2q36.3

SNPs ID: rs4674993

Mapped Gene: NYAP2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 20.0 (%)

Facial emotion recognition (angry faces)

Quantification of some aspect of facial emotion recognition such as ability to differentiate between different emotions

Region: 12p11.22

SNPs ID: rs4930838

Mapped Gene: CCDC91 - FAR2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 15.6 (%)

Cognitive performance

Tests designed to assess neurological function associated with certain behaviors. they are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.

Region: 13q31.2

SNPs ID: rs969962

Mapped Gene: TET1P1 - LINC00373

Group of disease/trait: Nervous system disease

020406080100Your Genetic Risk 13.98 (%)

Schizophrenia

A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality.

Region: 14q24.3

SNPs ID: rs7149373

Mapped Gene: NRXN3

Group of disease/trait: Mental disorder

020406080100Your Genetic Risk 11.5 (%)

Platelet count

The number of platelets per unit volume in a sample of venous blood.

Region: 11q24.3

SNPs ID: rs2268607

Mapped Gene: FLI1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 11.1 (%)

Plateletcrit

The proportion of blood volume that is occupied by platelets, expressed as a percentage.

Region: 11q24.3

SNPs ID: rs2268607

Mapped Gene: FLI1

Group of disease/trait: Other trait

020406080100Your Genetic Risk 11.1 (%)

Cigarettes smoked per day

the quantification of the number of cigarettes that a subject smoked on average per day

Region: 1q21.3

SNPs ID: rs2072659

Mapped Gene: CHRNB2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 10.6 (%)

Smoking behaviour (cigarettes smoked per day)

the quantification of the number of cigarettes that a subject smoked on average per day

Region: 1q21.3

SNPs ID: rs2072659

Mapped Gene: CHRNB2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 10.2 (%)

Cigarettes smoked per day (MTAG)

the quantification of the number of cigarettes that a subject smoked on average per day

Region: 1q21.3

SNPs ID: rs2072659

Mapped Gene: CHRNB2

Group of disease/trait: Other trait

020406080100Your Genetic Risk 9.86 (%)

Diastolic blood pressure

The blood pressure after the contraction of the heart while the chambers of the heart refill with blood.

Region: 2q35

SNPs ID: rs16859180

Mapped Gene: STK36

Group of disease/trait: Cardiovascular disease

020406080100Your Genetic Risk 4.93 (%)